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KMID : 0614020020170010055
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Journal of Pharmaceutical Sciences (C.N.U.)
2002 Volume.17 No. 1 p.55 ~ p.60
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Lymphoblastogenic Activity of Korean Basidiomycetes including Psathyrella candolleana
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Chang Hye-Jin
Lee Ji-Seon
Chung Kyeong-Soo
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Abstract
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As an effort to find out potent antitumor immunomodulatory agents from Korean basidiomycetes, the protein-polysaccharide fractions were prepared from ten mushrooms - Boletus fuscopunctatus, Collybia dryophila, Coriolus unicolor, Crepidotus sp., Galerina fasciculata. Lycoperdon pyriforme, Marasmius maximus, Psathyrella candolleana, Russula albonigra and subjected to a flow cytometrical analysis for their in vitro lymphoblastogenic activity. Among them, P. candolleana showed the most potent lymphoblastogenic effect on the BALB/c mouse splenic lymphocytes. On subtype analysis, P. candolleana was found to exert its lymphoblastogenic effect mostly on non T cells.
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KEYWORD
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Basidiomycetes, protein-polysaccharide, immunomodulatory agent, Psathyrella candolleana, flow cytometry, lymphoblast
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